The Influence of NF-KB in the development of autoimmunity and cancer in Fas/FasL mutant mice

NF-KB对Fas/FasL突变小鼠自身免疫和癌症发生的影响

• 批准号: nhmrc : 1009145
• 负责人: Dr Lorraine O'Reilly
• 金额: $ 39.8万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/influence-nf-kb-mutant-mice/109376
• 关键词: Influence; NF; KB; development; autoimmunity

Apoptotic cell death is an essential process in the human body, it removes useless and dangerous cells, preventing autoimmune disease and cancer. Apoptosis is activated when the surface receptor Fas is stimulated by its ligand, FasL, but defective signalling causes disease associated with deregulated NF-?B activation. We will investigate how faulty FasL-induced apoptosis cooperates with deregulated NF-kB activation or defective Aire (immunological tolerance orchestrator) results in autoimmunity.

细胞凋亡性死亡是人体内一个必不可少的过程，它可以清除无用和危险的细胞，预防自身免疫性疾病和癌症。当表面受体Fas被其配体FasL刺激时，细胞凋亡被激活，但信号缺陷会导致与解除调节的核因子-β激活相关的疾病。我们将研究缺陷的FasL诱导的细胞凋亡如何与去调节的NF-kB激活或缺陷的免疫耐受协调器(AIRE)协同导致自身免疫。