The interplay between viperin, peroxisomes and the cellular innate antiviral response
The interplay between viperin, peroxisomes and the cellular innate antiviral response
批准号:
nhmrc : 1145613
负责人:
A/Pr Michael Beard
金额:
$37.6万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31
中文摘要
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英文摘要
Infection with a virus initiates a cellular antiviral response that attempts to limit viral replication, however how this response is regulated is not well understood. In this proposal we will investigate a cellular protein (viperin) that can regulate this process by interaction with peroxisomes to amplify the antiviral response. This work will provide possible targets for therapeutic manipulation of the innate immune response that will be applicable to a wide range of viral infections.
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The interplay between viperin, peroxisomes and the cellular innate antiviral response
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批准号:nhmrc : GNT1145613
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项目类别:Project Grants
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资助金额:$55.61万
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财政年份:2018
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负责人:A/Pr Michael Beard
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依托单位:
Hepatitis C infection and disease
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批准号:nhmrc : GNT1053206
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项目类别:Programs
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资助金额:$542.79万
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财政年份:2014
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负责人:A/Pr Michael Beard
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依托单位:
Hepatitis C infection: epidemiology, pathogenesis, and treatment
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批准号:nhmrc : 1053206
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项目类别:Program Grants
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资助金额:$379.74万
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财政年份:2014
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负责人:A/Pr Michael Beard
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依托单位:
Imaging the hepatitis C virus life cycle in real-time
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批准号:nhmrc : 1027641
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项目类别:Project Grants
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资助金额:$31.84万
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财政年份:2012
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负责人:A/Pr Michael Beard
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依托单位:
Uncoupled Research Fellowship
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批准号:nhmrc : 626906
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项目类别:NHMRC Research Fellowships
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资助金额:$47.72万
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财政年份:2010
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负责人:A/Pr Michael Beard
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依托单位:
HIV and HCV Vaccines and Immunopathogenesis.
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批准号:nhmrc : 510448
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项目类别:Programs
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资助金额:$1249.87万
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财政年份:2009
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负责人:A/Pr Michael Beard
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依托单位:
Identification of interferon stimulated genes that limit HCV replication and predict therapeutic outcome
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批准号:nhmrc : 508088
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项目类别:NHMRC Project Grants
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资助金额:$25.95万
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财政年份:2008
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负责人:A/Pr Michael Beard
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依托单位:
The role of CXCR3 chemokines in hepatitis C and other forms of viral hepatitis
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批准号:nhmrc : 399285
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项目类别:NHMRC Project Grants
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资助金额:$30.49万
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财政年份:2006
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负责人:A/Pr Michael Beard
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依托单位:
The role of Cyp2e1, alcohol and HCV in modulation of hepatocyte homeostasis HCV replication and resistance to interferon
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批准号:nhmrc : 399284
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项目类别:NHMRC Project Grants
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资助金额:$30.37万
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财政年份:2006
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负责人:A/Pr Michael Beard
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依托单位:
Defining the hepatocyte response to HCV infection: its role in modulating liver disease and virus replication
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批准号:nhmrc : 349353
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项目类别:Career Development Fellowships
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资助金额:$30.24万
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财政年份:2005
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负责人:A/Pr Michael Beard
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依托单位:
Induction of Reactive Oxygen Species by Hepatitis C Virus and its Role in Liver Pathogenesis.
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批准号:nhmrc : 207817
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项目类别:NHMRC Project Grants
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资助金额:$25.09万
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财政年份:2002
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负责人:A/Pr Michael Beard
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依托单位:
海外基金