The interplay between viperin, peroxisomes and the cellular innate antiviral response

蝰蛇蛋白、过氧化物酶体和细胞先天抗病毒反应之间的相互作用

• 批准号: nhmrc : GNT1145613
• 负责人: A/Pr Michael Beard
• 金额: $ 55.61万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interplay-viperin-peroxisomes-antiviral-response/1348698
• 关键词: interplay; between; viperin; peroxisomes; cellular

Infection with a virus initiates a cellular antiviral response that attempts to limit viral replication, however how this response is regulated is not well understood. In this proposal we will investigate a cellular protein (viperin) that can regulate this process by interaction with peroxisomes to amplify the antiviral response. This work will provide possible targets for therapeutic manipulation of the innate immune response that will be applicable to a wide range of viral infections.

感染病毒会引发一种细胞抗病毒反应，试图限制病毒复制，但这种反应是如何调节的，目前还不清楚。在这项建议中，我们将研究一种细胞蛋白(毒蛇蛋白)，它可以通过与过氧化体相互作用来调节这一过程，从而放大抗病毒反应。这项工作将为治疗操作先天免疫反应提供可能的靶点，这将适用于广泛的病毒感染。