The Neural Control of Serotonin Release from Intestinal Enterochromaffin (EC) Cells

肠肠嗜铬细胞 (EC) 释放血清素的神经控制

• 批准号: nhmrc : 299803
• 负责人: Dr Paul Bertrand
• 金额: $ 7.81万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neural-control-serotonin-ec-cells/82207
• 关键词: Neural; Control; Serotonin; Release; Intestinal

Many functional gastrointestinal problems are believed to be caused by a disruption of the normal functioning of the nerves within the wall of the gut. These nerves are believed to receive information about the contents of the intestine from a specialised class of cell lining the inside wall of the gut called the enterochromaffin cell. The enterochromaffin cell does this job by modulating the release of the transmitter serotonin. In some disorders, like the Irritable Bowel Syndrome (IBS) which can affect the upper and lower intestine, the information that serotonin carries can become confused. Thus, the control of the release of serotonin from the enteroendocrine cell is an important process to understand in health and in disease. We will investigate this release directly in isolated tissues from guinea pig small and large intestine and from human large intestine. This study will examine the role of serotonin and the modulation of its release from the enterochromaffin cell. Problems with serotonin release may underlie disease, thus, understanding how this release is controlled will provide a foundation for new and specific therapies that target channels or receptors specific to the release of serotonin. These data could help to develop therapies for gastrointestinal problems such as the IBS, chronic intestinal pseudo-obstruction and gastro-oesophageal reflux disease. The release of serotonin is also intimately linked with the diarrhea associated with cholera and anti-cancer treatments. The proposed study will contribute to the ongoing development of specific therapies that block serotonin receptors on the nerve terminal and will lead to new therapies that compliment existing therapies by modulating the release of serotonin.

许多功能性胃肠道问题被认为是由肠壁内神经的正常功能破坏引起的。据信，这些神经从肠道内壁上的一类特殊细胞（称为肠嗜铬细胞）接收有关肠道内容物的信息。肠嗜铬细胞通过调节递质血清素的释放来完成这项工作。在某些疾病中，例如肠易激综合症（IBS），它会影响上肠和下肠，血清素携带的信息可能会变得混乱。因此，控制肠内分泌细胞释放血清素是了解健康和疾病的一个重要过程。我们将直接在豚鼠小肠、大肠以及人类大肠的分离组织中研究这种释放。这项研究将检查血清素的作用及其对肠嗜铬细胞释放的调节。血清素释放问题可能是疾病的根源，因此，了解如何控制这种释放将为针对血清素释放特异通道或受体的新的特定疗法奠定基础。这些数据可能有助于开发治疗肠易激综合征、慢性假性肠梗阻和胃食管反流病等胃肠道问题的疗法。血清素的释放也与霍乱和抗癌治疗相关的腹泻密切相关。拟议的研究将有助于阻断​​神经末梢血清素受体的特定疗法的持续开发，并将导致通过调节血清素释放来补充现有疗法的新疗法。