The NF-kB transcription factors c-Rel and RelA control multiple steps in natural CD4 regulatory T cell development

NF-kB 转录因子 c-Rel 和 RelA 控制天然 CD4 调节性 T 细胞发育的多个步骤

• 批准号: nhmrc : 1029822
• 负责人: Prof Steve Gerondakis
• 金额: $ 37.78万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nf-kb-transcription-cell-development/110713
• 关键词: NF; kB; transcription; factors; Rel

An unfortunate consequence of immune function is that occasionally rogue immune cells are produced that attack the host and lead to the development of so-called autoimmune diseases such as arthritis. Normally a white blood cell called a regulatory T cell suppresses these self-reactive immune cells. We have identified factors that govern the generation of regulatory T cells. Understanding how these factors work should permit the development of new strategies to combat autoimmune diseases. ?

免疫功能的一个不幸后果是，偶尔会产生攻击宿主的流氓免疫细胞，并导致所谓的自身免疫性疾病（例如关节炎）的发展。通常，一种称为调节性 T 细胞的白细胞会抑制这些自身反应性免疫细胞。我们已经确定了控制调节性 T 细胞生成的因素。了解这些因素如何发挥作用应该有助于制定对抗自身免疫性疾病的新策略。 ？