Roles of signalling in the control of immune system development, function and pathology

信号传导在控制免疫系统发育、功能和病理学中的作用

• 批准号: nhmrc : 1002580
• 负责人: Prof Steve Gerondakis
• 金额: $ 49.21万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/roles-signalling-control-function-pathology/108831
• 关键词: Roles; signalling; control; immune; system

This research focuses on the function of the NF-?B and MAP kinase biochemical pathways in immune cells. Both pathways regulate gene expression controlling the development, division, viability and function of immune cells. Consistent with these roles, impaired regulation of these pathways contributes to many immune related diseases. My goal is to utilize information learnt about these pathways and apply it to developing therapies for treating diseases afflicting the immune system.

本研究主要探讨NF-？免疫细胞中的B和MAP激酶生化途径。这两种途径调节基因表达，控制免疫细胞的发育、分裂、活力和功能。与这些作用一致，这些途径的调节受损导致许多免疫相关疾病。我的目标是利用关于这些途径的信息，并将其应用于开发治疗困扰免疫系统的疾病的疗法。