Antibodies against erythrocyte invasion ligands of Plasmodium falciparum and protection from malaria

抗恶性疟原虫红细胞侵袭配体的抗体和预防疟疾

• 批准号: nhmrc : 516756
• 负责人: Prof James Beeson
• 金额: $ 23.88万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/antibodies-erythrocyte-invasion-protection-malaria/81707
• 关键词: Antibodies; against; erythrocyte; invasion; ligands

Malaria is a leading cause of childhood death globally. Malaria parasites infect red blood cells and multiply inside them, resulting in severe illness if untreated. Currently there is no vaccine available and effective treatments are limited. In studies of children in Africa and PNG, we aim to identify immune responses that block infection and growth of malaria in the blood. With this knowledge, vaccines can be designed that target malaria to prevent serious illness and death.

疟疾是全球儿童死亡的主要原因。疟疾寄生虫感染红细胞并在其中繁殖，如果不治疗，会导致严重疾病。目前还没有疫苗可用，有效的治疗方法也有限。在对非洲和巴布亚新几内亚儿童的研究中，我们的目标是确定阻止疟疾在血液中感染和生长的免疫反应。有了这些知识，就可以设计针对疟疾的疫苗，以防止严重疾病和死亡。