Artificial synthesis of the type III secretion system translocon. A new approach to vaccine design

III型分泌系统易位子的人工合成。

• 批准号: nhmrc : GNT1129234
• 负责人: A/Pr Richard Berry
• 金额: $ 66.87万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/artificial-synthesis-type-vaccine-design/1347745
• 关键词: Artificial; synthesis; type; III; secretion

Today hospitals are plagued with bacterial infections that do not respond to antibiotics. The problem exists because although antibiotics are effective at killing bacteria, this paradoxically also helps the drug-resistant bacteria thrive. We will pioneer a completely new approach to vaccine design that allows us to construct a vaccine that protects us from bacterial infection without killing the bacteria. The vaccine should therefore be far less susceptible to drug resistance.

今天，医院被抗生素无效的细菌感染所困扰。这个问题的存在是因为尽管抗生素能有效杀死细菌，但矛盾的是，这也有助于耐药细菌的繁殖。我们将开创一种全新的疫苗设计方法，使我们能够构建一种保护我们免受细菌感染而不杀死细菌的疫苗。因此，这种疫苗对耐药性的敏感性要低得多。