The pathophysiology of septic acute kidney injury

脓毒症急性肾损伤的病理生理学

• 批准号: nhmrc : 1050672
• 负责人: Prof Clive May
• 金额: $ 31.82万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pathophysiology-septic-acute-kidney-injury/112168
• 关键词: pathophysiology; septic; acute; kidney; injury

Septic shock is a common clinical problem; it is frequently associated with kidney failure that increases mortality. We aim to determine the changes within the kidney that cause it to fail. We will establish whether oxygen levels and blood flow are altered within the kidney, and if blood is shunted through specific blood vessels, reducing flow in critical areas. Importantly, we will determine if clinical treatments used to improve kidney function cause long-term damage by reducing tissue oxygen.

感染性休克是一种常见的临床问题，它经常与肾衰竭，增加死亡率。我们的目标是确定导致肾脏衰竭的变化。我们将确定肾脏内的氧气水平和血流是否发生变化，以及血液是否通过特定血管分流，减少关键区域的流量。重要的是，我们将确定用于改善肾功能的临床治疗是否会通过减少组织氧而导致长期损害。