Is sympathetic activation beneficial or detrimental in septic shock?

交感神经激活对于感染性休克是有益还是有害？

• 批准号: nhmrc : 1009280
• 负责人: Prof Clive May
• 金额: $ 30.59万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/sympathetic-activation-beneficial-septic-shock/109389
• 关键词: sympathetic; activation; beneficial; detrimental; septic

Septic shock is a major cause of death in intensive care units. It is associated with large increases in sympathetic nerve activity to the heart and kidneys, which have both beneficial and harmful effects. This project will determine the responses to the increased sympathetic activity in septic shock, the causes of it and whether blocking this activation has an overall beneficial effect. This knowledge is essential before drugs that block sympathetic activation are examined in clinical studies.

感染性休克是重症监护病房的主要死亡原因。它与心脏和肾脏交感神经活动的大量增加有关，这既有有益的影响，也有有害的影响。该项目将确定对感染性休克中交感神经活性增加的反应，其原因以及阻断这种激活是否具有总体有益效果。在临床研究中检查阻断交感神经激活的药物之前，这些知识是必不可少的。