Association Between Sirtuin single nucleotide polymorphisms and functional markers of brain health in ageing

Sirtuins是一种组蛋白去乙酰化酶，在能量消耗、线粒体功能和代谢性疾病（特别是神经退行性疾病和阿尔茨海默病）的发病机制中起着关键作用。在这项研究中，我们将重点研究编码sirtuin家族的基因，并研究编码sirtuin家族基因内的单核苷酸多态性与大脑健康功能标记之间的关系。

Sirtuins are histone deacetylases that have been reported to play a pivotal role in energy expenditure, mitochondrial function and pathogenesis of metabolic diseases, including neurodegenerative disorders and Alzheimer’s disease in particular. In this study, we will focus on the genes encoding sirtuin families, and examined the association between single nucleotide polymorphisms within genes encoding sirtuin families and functional markers for brain health.