Association Between Sirtuin single nucleotide polymorphisms and functional markers of brain health in ageing

Sirtuin 单核苷酸多态性与衰老过程中大脑健康功能标志物之间的关联

• 批准号: nhmrc : 1054544
• 负责人: Dr Nady Braidy
• 金额: $ 20.79万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/association-sirtuin-single-health-ageing/112398
• 关键词: Association; Between; Sirtuin; single; nucleotide

Sirtuins are histone deacetylases that have been reported to play a pivotal role in energy expenditure, mitochondrial function and pathogenesis of metabolic diseases, including neurodegenerative disorders and Alzheimer’s disease in particular. In this study, we will focus on the genes encoding sirtuin families, and examined the association between single nucleotide polymorphisms within genes encoding sirtuin families and functional markers for brain health.

Sirtuins是组蛋白脱乙酰酶，已报道其在能量消耗、线粒体功能和代谢疾病（包括神经退行性疾病，特别是阿尔茨海默病）的发病机制中起关键作用。在本研究中，我们将专注于编码sirtuin家族的基因，并检查编码sirtuin家族的基因内的单核苷酸多态性和脑健康的功能标记之间的关联。