Continuous tooth replacement in mammals: revealing the fundamental processes in tooth generation and movement

哺乳动物的连续牙齿更换：揭示牙齿生成和运动的基本过程

• 批准号: FT130100968
• 负责人: Prof Alistair Evans
• 金额: $ 51.58万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-12-31 至 2019-12-28
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT130100968
• 关键词: Continuous; tooth; replacement; mammals; revealing

This project will investigate how molar teeth are made in mammals by examining the nabarlek, or little rock-wallaby, which is one of a handful of mammals that is able to regenerate new molars throughout its life. These new teeth migrate through the bone in order to move into the correct position in the mouth. By investigating two well-studied organisms, the mouse and the tammar wallaby, as well as the nabarlek itself, the developmental processes and genes involved in molar generation and movement will be revealed. This project will integrate findings in regenerative medicine, evolutionary biology, materials engineering and palaeontology to reveal the mechanisms and origins of this astounding capability.

这个项目将通过研究nabarlek或小岩袋鼠来研究哺乳动物的臼齿是如何形成的，这是少数几种能够在一生中再生新臼齿的哺乳动物之一。这些新牙齿通过骨骼迁移，以便移动到口腔中的正确位置。通过研究两种被充分研究的生物，老鼠和tammar小袋鼠，以及nabarlek本身，发育过程和涉及臼齿生成和运动的基因将被揭示。该项目将整合再生医学，进化生物学，材料工程和古生物学的研究结果，以揭示这种惊人能力的机制和起源。