A new universal mechanism controlling body proportions in animals

控制动物身体比例的新通用机制

• 批准号: DP180101797
• 负责人: Prof Alistair Evans
• 金额: $ 29.56万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180101797
• 关键词: new; universal; mechanism; controlling; body

This project aims to establish that a recently-discovered mechanism, the inhibitory cascade, determines the basic proportions of appendages and body segments in a diverse range of animal groups, particularly vertebrates and arthropods. The goals of the project are to reveal the molecular mechanisms in mice and insects, and build computer simulations to show how to manipulate the control of development by the inhibitory cascade. The project should benefit bioengineering by establishing control mechanisms for the manipulation and regeneration of teeth and limbs.

该项目旨在建立一种最近发现的机制，即抑制级联，决定了各种动物群体，特别是脊椎动物和节肢动物的附属物和身体部位的基本比例。该项目的目标是揭示小鼠和昆虫的分子机制，并建立计算机模拟来展示如何通过抑制级联来操纵控制发育。通过建立牙齿和肢体的操纵和再生的控制机制，该项目将有利于生物工程。