Bench to beside translational studies to develop treatments for preeclampsia

结合转化研究开发先兆子痫治疗方法

• 批准号: nhmrc : 1142636
• 金额: $ 18.07万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bench-translational-studies-treatments-preeclampsia/1319743
• 关键词: Bench; beside; translational; studies; develop

Preeclampsia is a common, devastating complication of pregnancy responsible for the loss of countless mothers and babies. There is no medical treatment. Excitingly we have identified 2 medications, safe in pregnancy: metformin and sulfasalazine that may treat this disease. We plan to introduce these medications into the clinic to see whether they may be an effective treatment for preeclampsia. If successful, these medications have the potential to improve the lives of women and babies globally.

先兆子痫是一种常见的、毁灭性的妊娠并发症，导致无数母亲和婴儿死亡。没有医疗手段。令人兴奋的是，我们已经确定了两种药物，在怀孕期间安全：二甲双胍和柳氮磺胺吡啶，可以治疗这种疾病。我们计划将这些药物引入临床，看看它们是否可能是治疗先兆子痫的有效方法。如果成功，这些药物有可能改善全球妇女和婴儿的生活。