Bioactive and biodegradable scaffold and novel graft source for the repair of large segmental bone defects

创伤和肿瘤引起的大面积骨缺损的治疗仍然是骨科医生面临的一个挑战。该项目结合了一种成熟的支架，可以定制以满足患者的特定需求，并结合了一种新的移植物来源，可以在最小的疼痛和发病率的情况下大量收获。这种新颖的组织工程方法将在先前建立的临床前模型中进行评估，该模型反映了具有挑战性的临床场景的严重性。

The treatment of large bone defects arising from trauma and tumour remains a challenge to orthopaedic surgeons. This project combines a well-established scaffold that can be custom-made to address patient specific requirements with a novel source of graft that can be harvested in significant volumes with minimal pain and morbidity. This novel tissue engineering approach will be evaluated in a previously established pre-clinical model that reflects the severity of challenging clinical scenarios.