Biodegradable Elastomers and Resorbable Synthetic Vascular Grafts
可生物降解的弹性体和可吸收的合成血管移植物
基本信息
- 批准号:10580321
- 负责人:
- 金额:$ 46.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-03-15 至 2026-02-28
- 项目状态:未结题
- 来源:
- 关键词:AdhesionsAlkynesAnimal ModelAnimalsArteriesAutologousAutologous TransplantationBlood PlateletsBypassCause of DeathCell Culture TechniquesCellsChemistryClinicalCoronary Artery BypassDataData AnalysesDepositionDiameterDiseaseElasticityElastomersElectrospinningEndotheliumEngineeringEvaluationExtracellular MatrixFemaleFiberFutureGlycerolHeparinImmobilizationImmune responseImplantIn SituIn VitroInfiltrationLegal patentLengthModelingModulusMolecular WeightMorphologyNatural regenerationOutcomePatientsPerformancePeripheralPolyestersPolymersPorosityPositron-Emission TomographyProliferatingPropertyRattusRegenerative capacityResearchResourcesStainsStenosisStructureSulfhydryl CompoundsSurfaceSurgical suturesTechniquesTemperatureTensile StrengthThickThrombosisTissuesTrainingTunica AdventitiaUnderrepresented StudentsVascular Graftabdominal aortaabsorptionbiodegradable polymerbiomaterial compatibilitycaprolactonecrosslinkcrystallinitydesignelastomericfabricationhydrophilicitymalemechanical propertiesmonomerpediatric patientsrecruitscaffoldsebacic acidserinolstandard carethrombotictranslational studyundergraduate student
项目摘要
Project Summary
Occlusive artery diseases are a leading cause of death worldwide. Only in the U.S., there are
approximately 400,000 coronary artery bypasses and 460,000 peripheral artery bypasses performed each year.
Autografts are the gold-standard treatment. However, approximately 1/3 of these patients are unable to take this
treatment because of limited autologous resources. Nondegradable grafts (e.g., PET and ePTFE) have been
alternative to the autografts over the years, but they perform poorly in small arteries (< 6 mm) due to thrombosis,
stenosis, and low patency rate. On the other hand, bioresorbable grafts have been proposed for in situ arterial
regeneration using the host regenerative capacities. The complications occurred in the nondegradable grafts
can be minimized. However, none of the currently existing biodegradable polymers have produced a clinically
useful resorbable graft.
In this proposal, we seek to synthesize new biodegradable functional polyester elastomers and use to
engineer fully resorbable synthetic grafts with tunable degradation, mechanical properties, and hydrophilicity.
We expect the fully remodeled grafts can grow along with native arteries, which is particularly important for
pediatric patients. There are three main objectives in this proposal. Objective 1: Design, synthesis and
characterization of the biodegradable functional polyester elastomers using endogenous and biocompatible
monomers. Objective 2: Engineer anti-thrombotic fibrous grafts with tunable degradation and mechanical
properties. Objective 3: Evaluation of candidate grafts in rat abdominal aorta interposition models for in situ
arterial regeneration. Data from this project will be used to optimize the graft parameters for large animal studies
in the future, given a quicker degradation and slower regenerative capacities in large animals. Undergraduate
students including underrepresented students will be recruited and trained to conduct research in this project,
such as material synthesis and characterizations, graft fabrication and characterizations, cell culture studies, and
tissue section, staining and data analyses, among others.
项目总结
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
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专利数量(0)
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