权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Biodegradable Elastomers and Resorbable Synthetic Vascular Grafts

可生物降解的弹性体和可吸收的合成血管移植物

基本信息

批准号：
10580321
负责人：
Xiaochu Ding
金额：
$ 46.95万
依托单位：
MICHIGAN TECHNOLOGICAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-03-15 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10580321
关键词：
Adhesions Alkynes Animal Model Animals Arteries Autologous Autologous Transplantation Blood Platelets Bypass Cause of Death Cell Culture Techniques Cells Chemistry Clinical Coronary Artery Bypass Data Data Analyses Deposition Diameter Disease Elasticity Elastomers Electrospinning Endothelium Engineering Evaluation Extracellular Matrix Female Fiber Future Glycerol Heparin Immobilization Immune response Implant In Situ In Vitro Infiltration Legal patent Length Modeling Modulus Molecular Weight Morphology Natural regeneration Outcome Patients Performance Peripheral Polyesters Polymers Porosity Positron-Emission Tomography Proliferating Property Rattus Regenerative capacity Research Resources Stains Stenosis Structure Sulfhydryl Compounds Surface Surgical sutures Techniques Temperature Tensile Strength Thick Thrombosis Tissues Training Tunica Adventitia Underrepresented Students Vascular Graft abdominal aorta absorption biodegradable polymer biomaterial compatibility caprolactone crosslink crystallinity design elastomeric fabrication hydrophilicity male mechanical properties monomer pediatric patients recruit scaffold sebacic acid serinol standard care thrombotic translational study undergraduate student

项目摘要

Project Summary Occlusive artery diseases are a leading cause of death worldwide. Only in the U.S., there are approximately 400,000 coronary artery bypasses and 460,000 peripheral artery bypasses performed each year. Autografts are the gold-standard treatment. However, approximately 1/3 of these patients are unable to take this treatment because of limited autologous resources. Nondegradable grafts (e.g., PET and ePTFE) have been alternative to the autografts over the years, but they perform poorly in small arteries (< 6 mm) due to thrombosis, stenosis, and low patency rate. On the other hand, bioresorbable grafts have been proposed for in situ arterial regeneration using the host regenerative capacities. The complications occurred in the nondegradable grafts can be minimized. However, none of the currently existing biodegradable polymers have produced a clinically useful resorbable graft. In this proposal, we seek to synthesize new biodegradable functional polyester elastomers and use to engineer fully resorbable synthetic grafts with tunable degradation, mechanical properties, and hydrophilicity. We expect the fully remodeled grafts can grow along with native arteries, which is particularly important for pediatric patients. There are three main objectives in this proposal. Objective 1: Design, synthesis and characterization of the biodegradable functional polyester elastomers using endogenous and biocompatible monomers. Objective 2: Engineer anti-thrombotic fibrous grafts with tunable degradation and mechanical properties. Objective 3: Evaluation of candidate grafts in rat abdominal aorta interposition models for in situ arterial regeneration. Data from this project will be used to optimize the graft parameters for large animal studies in the future, given a quicker degradation and slower regenerative capacities in large animals. Undergraduate students including underrepresented students will be recruited and trained to conduct research in this project, such as material synthesis and characterizations, graft fabrication and characterizations, cell culture studies, and tissue section, staining and data analyses, among others.

项目总结