Biochemical and structural analysis of virus-host interactions during HIV-1 assembly

HIV Gag是指导感染性HIV形成的最重要的蛋白质。世界各地的研究人员都很难产生用于生化和结构分析的全长HIV Gag。我们已经开发了一种新的方法来制备大量的HIV Gag，本项目将利用我们的发现来确定HIV Gag的生化和结构特征，最终通过合理的药物设计开发新的治疗药物。

HIV Gag is the most important protein to direct the formation of infectious HIV. Researchers everywhere have had significant difficulty to generate full length HIV Gag for biochemical and structural analysis. We have since developed a novel way to prepare large amount of HIV Gag, and this project will take advantage of our discovery to determine the biochemical and the structural features of HIV Gag, ultimately, for the development of novel therapeutics through rational drug design.