Bioresponsive Porous Silicon for Site Specific Oral Delivery of Antibodies for the Treatment of Inflammatory Bowel Disease

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This proposal aims to develop an oral antibody delivery system for treatment of inflammatory bowel disease (IBD) that affects 75000 Australians. The system will be based on porous silicon nanoparticles acting as a container to protect the antibodies, and bioresponsive coatings acting as gates to enable site specific protein delivery at the inflamed site of GI tract. The project not only holds promise for protein delivery for the treatment of IBD but other diseases like diabetes.