Breaking malaria's lethal grip: Targeting the assembly of an adhesive complex on infected red blood cells

打破疟疾的致命控制：针对受感染红细胞上的粘合剂复合物的组装

• 批准号: nhmrc : GNT1078065
• 负责人: Dr Matthew Dixon
• 金额: $ 79.22万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/breaking-malarias-lethal-blood-cells/1345184
• 关键词: Breaking; malaria; lethal; grip; Targeting

The malaria parasite, Plasmodium falciparum, infects the red blood cells of its human victims. It causes them to stick to blood vessel walls in the brain, causing severe cerebral complications and death. Adhesion is mediated by a Velcro-like protein that is presented at the red blood cell surface. This project will fully elucidate the pathway for trafficking of the adhesion protein to the red blood cell surface with a view to finding new ways of interfering with malaria disease.

疟疾寄生虫，恶性疟原虫，感染人类受害者的红细胞。它会使它们粘在大脑的血管壁上，导致严重的大脑并发症和死亡。粘附由存在于红细胞表面的Velcro样蛋白介导。该项目将充分阐明粘附蛋白运输到红细胞表面的途径，以期找到干预疟疾疾病的新方法。