使用小分子开发合成基因驱动器-猫眼课题宝

使用小分子开发合成基因驱动器

批准号：

10470220

负责人：

Omar Sultan Akbari

金额：

$35.73万

依托单位：

BRIGHAM AND WOMEN'S HOSPITAL

依托单位国家：

美国

项目类别：

财政年份：

2019

资助国家：

美国

项目状态：

已结题

起止时间：

2019-09-01 至 2024-01-31

来源：

https://reporter.nih.gov/project-details/10470220

关键词：

Acute Adverse effects Alleles Animal Husbandry Biomedical Technology Bypass CRISPR/Cas technology Chemistry Clustered Regularly Interspaced Short Palindromic Repeats Complex Computer Models Country Dengue Fever Development Disease Dose Drosophila genus Ecosystem Endemic Diseases Engineered Gene Engineering Environment Food Foundations Gene Activation Genes Genetic Genetic Engineering Guide RNA Heterogeneity Heterozygote Homozygote India Investigation Laboratories Lethal Genes Malaria Mediating Methodology Methods Modeling Mosaicism Organism Output Parasites Parents Plants Population Population Control Population Dynamics Prodrugs Streptococcus pyogenes Synthetic Genes System Technology Time Trimethoprim Ubiquitination Vector-transmitted infectious disease base computer studies gene drive system inhibitor insight mathematical model microbiome mimicry multicatalytic endopeptidase complex next generation nuclease pesticide resistance repaired screening small molecule small molecule inhibitor tool trait ubiquitin ligase vector control

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英文摘要

PROJECT SUMMARY Gene drives enable a super-Mendelian inheritance where the chance of passing on the gene to the progeny is 100%, and this super-Mendelian inheritance has been demonstrated for several engineered genes in multiple organisms. Gene-drive mediated trait propagation in the entire ecosystem may find use in the elimination of diseases (e.g., malaria, dengue fever) or invasive species, and reversing the pesticide resistance in plants. We propose to use tools and principles of chemistry to develop controllers that will allow us to understand the strength and limitations of the gene drive technologies.

期刊论文(2)

专著(0)

科研奖励(0)

会议论文

Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes.

DOI： 10.1021/acscentsci.0c00129

发表时间： 2020-12-23

期刊：

ACS central science

影响因子： 18.2

作者：

[Sreekanth V, Zhou Q, Kokkonda P, Bermudez-Cabrera HC, Lim D, Law BK, Holmes BR, Chaudhary SK, Pergu R, Leger BS, Walker JA, Gifford DK, Sherwood RI, Choudhary A]

通讯作者： Choudhary A

Chemical and optical control of CRISPR-associated nucleases.

DOI： 10.1016/j.cbpa.2020.10.003

发表时间： 2021-02-01

期刊：

Current opinion in chemical biology

影响因子： 7.8

作者：

[Modell, Ashley E, Siriwardena, Sachini U, Choudhary, Amit]

通讯作者： Choudhary, Amit