Broad Spectrum Inhibition of an Enzyme Antibiotic Target

酶抗生素靶标的广谱抑制

• 批准号: nhmrc : GNT1091976
• 负责人: Dr Tatiana Soares da Costa
• 金额: $ 30.94万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/broad-spectrum-inhibition-antibiotic-target/1345861
• 关键词: Broad; Spectrum; Inhibition; Enzyme; Antibiotic

There is a well-documented need to replenish the antibiotic pipeline with new products to combat the rise of drug resistant bacteria. In this project, the enzyme dihydrodipicolinate synthase (DHDPS) is targetted which is essential to bacterial viability. A number of independent but synergistic drug discovery approaches are investigated to develop and test DHDPS inhibitors in the pursuit of a novel class of antibiotics.

有充分的证据表明，有必要用新产品补充抗生素管道，以对抗抗药性细菌的崛起。在这个项目中，二氢二氢吡啶甲酸合成酶(DHDPS)是针对细菌生存所必需的。研究了一些独立但协同的药物发现方法，以开发和测试DHDPS抑制剂，以追求一类新的抗生素。