Re-purposing shelved 'antibiotics' in the search for new herbicides

重新利用搁置的“抗生素”寻找新的除草剂

• 批准号: DP220101901
• 负责人: Dr Tatiana Soares da Costa
• 金额: $ 31.84万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-06-02 至 2025-06-01
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101901
• 关键词: Re; purposing; shelved; antibiotics; search

This project aims to identify target-specific herbicidal compounds that inhibit amino acid biosynthesis pathways to tackle herbicide resistance. This project expects to validate a novel herbicide discovery strategy by exploiting the similarity between bacterial and plant enzymes in these pathways to re-purpose failed 'antibiotics'. Expected outcomes include advances in our knowledge of the structure, function and inhibition of novel herbicide targets, and the identification of compounds with herbicidal activity. This should lay the foundations for long-term benefits related to improving the quantity and quality of Australia’s crops to ensure our food security.

该项目旨在鉴定靶标特异性除草剂化合物，以抑制氨基酸生物合成途径以应对除草剂耐药性。该项目希望通过利用这些途径中的细菌和植物酶之间的相似性来验证一种新型的除草剂发现策略，以重新使用“抗生素”。预期的结果包括我们对新型除草剂靶标的结构，功能和抑制的了解以及具有除草剂活性的化合物的鉴定。这应该为与改善澳大利亚农作物的数量和质量相关的长期利益奠定基础，以确保我们的粮食安全。