Building better ex vivo 3D cancer models with 3D printing

三维细胞球，称为球体，是体内更好的肿瘤模型，比平面上的细胞培养更好，但在高通量生产方面具有挑战性。在这个项目中，我们将使用定制设计的3D打印机和新型生物墨水来模拟球体周围发现的蛋白质，以制作更好的体内癌症体外模型。这些生物墨水将被调整以模拟不同的组织，并显示治疗药物的传递如何受到椭圆形结构的影响。

Three dimensional balls of cells, called spheroids, are better models of tumours in vivo than cells plated on flat surfaces but are challenging to produce in high throughput. In this project we will use a custom designed 3D printer and novel bioinks that mimics of the proteins found around spheroids to make better in vitro models of in vivo cancers. These bioinks will be tuned to mimic different tissues and show how the delivery of therapeutics are affected by the spheroid architectures.