Calcium signaling and epithelial-mesenchymal transition: a new approach to identifying pharmacological targets for metastasis

钙信号传导和上皮间质转化：识别转移药理学靶点的新方法

• 批准号: nhmrc : 1022263
• 负责人: Prof Erik Thompson
• 金额: $ 37.45万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/calcium-signaling-epithelial-targets-metastasis/110179
• 关键词: Calcium; signaling; epithelial; mesenchymal; transition

The largest killer of women with breast cancer is disease that has spread e.g. to brain, bones, lungs. Once breast cancer has spread in this way to secondary sites, also known as metastatic disease, then there is limited treatment available and generally therapy is palliative only. Our work describes experiments that will help us understand the process of metastasis and provide new avenues for drug discovery in metastatic disease, thus helping women who have a poor prognosis.

乳腺癌妇女的最大杀手是已经扩散到脑、骨、肺等部位的疾病。一旦乳腺癌以这种方式扩散到继发部位，也称为转移性疾病，那么可用的治疗就有限了，通常治疗只能是姑息性的。我们的工作描述的实验将帮助我们了解转移的过程，并为转移性疾病的药物发现提供新的途径，从而帮助预后不良的妇女。