CBS domain modulation of muscle chloride channels; molecular mechanism and physiological role.

CBS 结构域调节肌肉氯离子通道；

• 批准号: nhmrc : 566672
• 负责人: Dr Brett Cromer
• 金额: $ 34.9万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cbs-domain-modulation-physiological-role/95596
• 关键词: CBS; domain; modulation; muscle; chloride

Muscle chloride channels regulate how readily muscles are activated, particularly during muscle fatigue. Recently we have identified a feed-back mechanism linking chloride channel function to muscle acidosis and energy depletion, key factors in fatigue. Here we will investigate the molecular details of this mechanism and its role in muscle physiology and fatigue. This mechanism may present a future target for the treatment of myotonia, a condition where muscles are too readily activated.

肌肉氯离子通道调节肌肉激活的容易程度，特别是在肌肉疲劳期间。最近，我们已经确定了一种反馈机制，将氯离子通道功能与肌肉酸中毒和能量消耗（疲劳的关键因素）联系起来。在这里，我们将研究这种机制的分子细节及其在肌肉生理学和疲劳中的作用。这种机制可能是未来治疗肌强直的一个目标，肌强直是一种肌肉太容易被激活的疾病。