Structural studies of the GABA receptor

GABA受体的结构研究

• 批准号: nhmrc : 247901
• 负责人: Dr Brett Cromer
• 金额: $ 56.94万
• 依托单位: St. Vincent's Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-studies-gaba-receptor/95387
• 关键词: Structural; studies; GABA; receptor

This proposal concerns the biochemical investigation of a protein called GABA receptor which is a known target for various anti-anxiety drugs (anxiolytics), anti-convulsants, sedatives, depressants, anti-epilespy drugs, alcohol and anaesthetics. This work is expected to lead to the determination of the three-dimensional shape of the protein which will provide essential information about how the protein works and lay the foundation for the design and development of new drugs to control epilepsy, act as general anaesthetics, relieve anxiety and induce sleep.

这项建议涉及一种称为GABA受体的蛋白质的生物化学研究，这种蛋白质是各种抗焦虑药物（抗焦虑药）、抗惊厥药、镇静剂、抑郁剂、抗癫痫药、酒精和麻醉剂的已知靶点。这项工作预计将导致确定蛋白质的三维形状，这将提供有关蛋白质如何工作的重要信息，并为设计和开发控制癫痫的新药奠定基础，作为全身麻醉剂，缓解焦虑和诱导睡眠。