CD8 T cell regulation of humoral immune responses

我们的身体依赖于产生有效的，或“高亲和力”的抗体来对抗感染。我们已经发现，在特定免疫细胞亚群耗尽后，抗体应答出乎意料地增强。对于抗体生产能力差的B细胞尤其如此。我们的发现可能与以下方面有关：（1）针对具有重要CTL和抗体组分的感染因子（例如HIV）的疫苗设计，（2）用于治疗用途（例如癌症）的抗体的改进生产。

Our bodies rely on the production of potent, or ‘high affinity’, antibodies to fight infection. We have found that antibody responses are unexpectedly boosted following the depletion of a specific subset of immune cells. This is especially true for B cells that are poor antibody producers. Our findings are likely to be relevant to (1) the design of vaccines to infectious agents that have important CTL and antibody components (e.g. HIV), (2) for the improved production of antibody for therapeutic use (e.g. cancer).