Interleukin signalling in CD4+ T cell differentiation
Interleukin signalling in CD4+ T cell differentiation
批准号:
nhmrc : 1087408
负责人:
A/Pr Cecile King
金额:
$44.27万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2018-12-31
中文摘要
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英文摘要
Our bodies rely on the production of antibodies to fight infection. The cytokine IL-21 is produced by immune cells called T follicular helper (Tfh) cells that help B cells make antibodies. Tfh cells, in turn, are controlled by regulatory (Tfr) cells. Our findings demonstrate that IL-21 supports Tfh cells and limits Tfr cells, thus favoring antibody production and long term immunity. Using genomic and cellular approaches, the mechanism(s) underlying these observations will be explored.
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Mechanisms of Action of Interleukin-2 Superkines
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批准号:nhmrc : GNT1148051
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项目类别:Project Grants
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资助金额:$72.56万
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财政年份:2018
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负责人:A/Pr Cecile King
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依托单位:
Mechanisms of Action of Interleukin-2 Superkines
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批准号:nhmrc : 1148051
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项目类别:Project Grants
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资助金额:$49.06万
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依托单位:
Interleukin signalling in CD4+ T cell differentiation
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批准号:nhmrc : GNT1087408
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项目类别:Project Grants
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资助金额:$64.31万
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财政年份:2015
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Identifying the ontogeny and fate of T follicular helper cells by two-photon photoconversion
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批准号:nhmrc : 1062332
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财政年份:2014
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CCR9 expressing T helper cells in immunity and autoimmunity
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批准号:nhmrc : 1066243
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财政年份:2014
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CD8 T cell regulation of humoral immune responses
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批准号:nhmrc : 1029942
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财政年份:2012
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负责人:A/Pr Cecile King
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依托单位:
T helper cytokines in immunity and organ-specific autoimmunity
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项目类别:Career Development Fellowships
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财政年份:2011
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负责人:A/Pr Cecile King
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依托单位:
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财政年份:2011
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依托单位:
The role of linked cytokines in T helper cell differentiation
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项目类别:NHMRC Project Grants
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财政年份:2010
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依托单位:
The role of Interleukin-21 in the pathogenesis of autoimmune diabetes
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批准号:nhmrc : 535934
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项目类别:NHMRC Project Grants
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资助金额:$32.61万
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财政年份:2009
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负责人:A/Pr Cecile King
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依托单位:
The role of Interleukin-21 in the pathogenesis of autoimmune diabetes
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批准号:nhmrc : 358307
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项目类别:NHMRC Project Grants
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资助金额:$34.61万
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财政年份:2005
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负责人:A/Pr Cecile King
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依托单位:
国内基金
海外基金
富含半胱氨酸分泌亚家族3蛋白与钙释放通道的相互作用
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批准号:30870508
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项目类别:面上项目
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资助金额:36.0万元
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批准年份:2008
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负责人:尹长城
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依托单位:
信号转导分子PAK4相互作用蛋白质的筛选
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批准号:30370736
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项目类别:面上项目
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资助金额:20.0万元
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批准年份:2003
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负责人:李丰
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依托单位: