Electrophysiological and pharmacological investigation of hippocampal formation function

海马形成功能的电生理和药理学研究

• 批准号: 9935-2006
• 负责人: Bland, Brian
• 金额: $ 3.28万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2006
• 资助国家: 加拿大
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=333343
• 关键词: Electrophysiological; pharmacological; investigation; hippocampal; formation

The long-term objective of my research program is to contribute to the understanding of the functions of the hippocampal formation and related structures (limbic cortex). My guiding hypothesis has been that these structures play a major role in sensorimotor integration. Specifically, I've posited that specific components of the of the neural circuitry in limbic cortex function in the capacity of providing voluntary motor systems with continually updated feedback on their performance relative to changing environmental (sensory) conditions. A crucial aspect of this performance is the intensity with which the motor programs are initiated and maintained. The components of the neural circuitry involved in sensorimotor integration are those underlying the production of oscillation and synchrony (theta) in limbic cortex. Brain rhythms such as theta band oscillation and synchrony appear to represent a basic mode of operation of large neural networks, allowing for the selective processing of information related to perceptual and behavioral states. Theta band oscillation and synchrony is a sinusoidal-like waveform with amplitude up to 2 mV and a narrow band frequency range of 3-12 Hz. The ultimate understanding of the functional significance of theta band oscillation and synchrony in limbic cortex will ultimately contribute to our understanding and treatment of hippocampal pathologies such Alzheimer's disease and epilepsies.

我的研究计划的长期目标是促进对海马体形成和相关结构（边缘皮质）功能的理解。我的指导假设是，这些结构在感觉运动整合中起着重要作用。具体来说，我假设边缘皮层神经回路的特定组成部分的功能是为自主运动系统提供不断更新的反馈，以反映它们相对于不断变化的环境（感官）条件的表现。这种表现的一个关键方面是运动程序启动和维持的强度。参与感觉运动整合的神经回路的组成部分是那些在边缘皮层产生振荡和同步（θ）的基础。大脑节律，如theta波段振荡和同步，似乎代表了大型神经网络的基本运作模式，允许选择性地处理与感知和行为状态相关的信息。θ波段振荡和同步是一种类似正弦的波形，振幅可达2 mV，窄带频率范围为3-12 Hz。最终了解边缘皮层θ波振荡和同步的功能意义，将最终有助于我们对阿尔茨海默病和癫痫等海马病理的理解和治疗。