Optical Metasurface for Single Small Extracellular Vesicle Analysis

用于单个小细胞外囊泡分析的光学超表面

• 批准号: DE240100321
• 负责人: Dr Ying Zhu
• 金额: $ 31.16万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE240100321
• 关键词: Optical; Metasurface; Single; Small; Extracellular

This project aims to develop an innovative nanobiotechnology to study small extracellular vesicles (sEVs) – small biological particles that are important in intercellular communication. The technology will enable unprecedented depth of analysis and single particle resolution. It will generate new knowledge in both engineering and biological sciences by improving sEV image resolution and collecting information regarding the distribution of different sEV subpopulations based on their protein phenotypes. Expected outcomes include a universal and ultrasensitive platform with many applications in analytical biochemistry such as disease diagnostics, environmental sciences, food safety and agriculture.

该项目旨在开发一种创新的纳米生物技术来研究小型细胞外蔬菜（SEV） - 在细胞间通信中很重要的小生物学颗粒。该技术将实现前所未有的分析深度和单个粒子分辨率。它将通过改善SEV图像分辨率并根据其蛋白质表型来收集有关不同SEV亚群的分布的信息，从而在工程和生物科学中产生新知识。预期的结果包括一个通用和超敏感的平台，在分析生物化学中有许多应用，例如疾病诊断，环境科学，食品安全和农业。