Cell Death Pathways and Type 1 Diabetes
Cell Death Pathways and Type 1 Diabetes
批准号:
nhmrc : 466658
负责人:
A/Pr Helen Thomas
金额:
$202.04万
依托单位国家:
澳大利亚
项目类别:
NHMRC Strategic Awards
财政年份:
2007
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2007-01-01 至 2012-12-31
中文摘要
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英文摘要
Loss of insulin-producing beta cells leads to type 1 diabetes and rejection of allogeneic islet transplants. The aim of this program is to discover ways of protecting beta cells from damage. We will do this by investigating whether blocking crucial regulators of cell death can protect mouse and human beta cells from destruction in vitro and in vivo. In doing so, we aim to prevent diabetes in mice and potentially improve the survival of islet grafts after transplantation.
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会议论文
Repurposing JAK inhibitors to treat type 1 diabetes
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批准号:nhmrc : 1145507
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项目类别:Project Grants
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资助金额:$64.09万
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财政年份:2018
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负责人:A/Pr Helen Thomas
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依托单位:
Repurposing JAK inhibitors to treat type 1 diabetes
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批准号:nhmrc : GNT1145507
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项目类别:Project Grants
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资助金额:$94.79万
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财政年份:2018
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负责人:A/Pr Helen Thomas
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依托单位:
Prevention of pancreatic beta cell destruction in diabetes
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批准号:nhmrc : 1042735
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项目类别:Research Fellowships
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资助金额:$41.44万
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财政年份:2013
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负责人:A/Pr Helen Thomas
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依托单位:
Pathogenesis-based treatment of type 1 diabetes
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批准号:nhmrc : 1037321
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项目类别:Program Grants
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资助金额:$720.7万
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财政年份:2013
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负责人:A/Pr Helen Thomas
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依托单位:
Glucose toxicity-induced activation of the Bcl-2-regulated apoptotic pathway in pancreatic beta cells
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批准号:nhmrc : 1032610
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项目类别:Project Grants
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资助金额:$41.16万
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财政年份:2012
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负责人:A/Pr Helen Thomas
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依托单位:
Prevention of pancreatic beta cell destruction in type 1 diabetes
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批准号:nhmrc : 620232
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项目类别:Career Development Fellowships
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资助金额:$21.63万
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财政年份:2010
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负责人:A/Pr Helen Thomas
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依托单位:
Apoptotic pathways in pancreatic beta cells leading to type 1 diabetes and transplant rejection
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批准号:nhmrc : 502605
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项目类别:NHMRC Project Grants
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资助金额:$35.7万
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财政年份:2008
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负责人:A/Pr Helen Thomas
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依托单位:
Mechansims of T cell-dependent pancreatic cell destruction
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批准号:nhmrc : 345433
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项目类别:Career Development Fellowships
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资助金额:$30.24万
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财政年份:2005
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负责人:A/Pr Helen Thomas
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依托单位:
T-cell mechanisms of B-cell destruction
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批准号:nhmrc : 219168
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项目类别:NHMRC Strategic Awards
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资助金额:$206.37万
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财政年份:2001
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负责人:A/Pr Helen Thomas
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依托单位:
Expression of dominant negative mutant interferon gamma receptors in pancreatic beta cells
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批准号:nhmrc : 977475
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项目类别:NHMRC Postgraduate Scholarships
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资助金额:$4.07万
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财政年份:1997
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负责人:A/Pr Helen Thomas
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依托单位:
国内基金
海外基金
亚麻LuMOD1(mosaic death 1)基因调控种子大小的分子机理研究
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批准号:
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项目类别:青年科学基金项目
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资助金额:--
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批准年份:2024
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负责人:江海霞
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依托单位:
炎性反应中巨噬细胞激活诱导死亡(activation-induced cell death,AICD)的机理研究
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批准号:30330260
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项目类别:重点项目
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资助金额:105.0万元
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批准年份:2003
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负责人:顾军
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依托单位: