Apoptotic pathways in pancreatic beta cells leading to type 1 diabetes and transplant rejection
Apoptotic pathways in pancreatic beta cells leading to type 1 diabetes and transplant rejection
批准号:
nhmrc : 502605
负责人:
A/Pr Helen Thomas
金额:
$35.7万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
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英文摘要
The destruction of insulin-producing beta cells in the pancreas by immune cells leads to the need for daily insulin injections in patients with type 1 diabetes. This project aims to understand how beta cells are destroyed. A knowledge of the process by which this occurs will indicate ways we can protect these cells. Our previous work has suggested strategies that may protect beta cells, and we aim to test these. Such protection may eventually allow beta cell replacement by transplantation.
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Repurposing JAK inhibitors to treat type 1 diabetes
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批准号:nhmrc : 1145507
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项目类别:Project Grants
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资助金额:$64.09万
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财政年份:2018
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负责人:A/Pr Helen Thomas
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依托单位:
Repurposing JAK inhibitors to treat type 1 diabetes
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批准号:nhmrc : GNT1145507
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项目类别:Project Grants
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资助金额:$94.79万
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财政年份:2018
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负责人:A/Pr Helen Thomas
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依托单位:
Prevention of pancreatic beta cell destruction in diabetes
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批准号:nhmrc : 1042735
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项目类别:Research Fellowships
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资助金额:$41.44万
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财政年份:2013
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负责人:A/Pr Helen Thomas
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依托单位:
Pathogenesis-based treatment of type 1 diabetes
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批准号:nhmrc : 1037321
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项目类别:Program Grants
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资助金额:$720.7万
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财政年份:2013
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负责人:A/Pr Helen Thomas
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依托单位:
Glucose toxicity-induced activation of the Bcl-2-regulated apoptotic pathway in pancreatic beta cells
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批准号:nhmrc : 1032610
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项目类别:Project Grants
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资助金额:$41.16万
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财政年份:2012
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负责人:A/Pr Helen Thomas
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依托单位:
Prevention of pancreatic beta cell destruction in type 1 diabetes
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批准号:nhmrc : 620232
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项目类别:Career Development Fellowships
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资助金额:$21.63万
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财政年份:2010
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负责人:A/Pr Helen Thomas
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依托单位:
Cell Death Pathways and Type 1 Diabetes
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批准号:nhmrc : 466658
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项目类别:NHMRC Strategic Awards
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资助金额:$202.04万
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财政年份:2007
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负责人:A/Pr Helen Thomas
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依托单位:
Mechansims of T cell-dependent pancreatic cell destruction
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批准号:nhmrc : 345433
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项目类别:Career Development Fellowships
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资助金额:$30.24万
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财政年份:2005
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负责人:A/Pr Helen Thomas
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依托单位:
T-cell mechanisms of B-cell destruction
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批准号:nhmrc : 219168
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项目类别:NHMRC Strategic Awards
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资助金额:$206.37万
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财政年份:2001
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负责人:A/Pr Helen Thomas
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依托单位:
Expression of dominant negative mutant interferon gamma receptors in pancreatic beta cells
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批准号:nhmrc : 977475
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项目类别:NHMRC Postgraduate Scholarships
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资助金额:$4.07万
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财政年份:1997
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负责人:A/Pr Helen Thomas
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依托单位:
国内基金
海外基金
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