Central glutamatergic pathways regulating the circadian rhythms of the autonomic nervous system and the autonomic response to sleep apnea.

中枢谷氨酸通路调节自主神经系统的昼夜节律和对睡眠呼吸暂停的自主反应。

• 批准号: nhmrc : 1052674
• 负责人: Dr Stephen Abbott
• 金额: $ 24.59万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/central-glutamatergic-pathways-sleep-apnea/112291
• 关键词: Central; glutamatergic; pathways; regulating; circadian

The central pathways of autonomic regulation are well known, but the functions of specific pathways in physiological settings remains an elusive goal. We will evaluate the role of two physiologically important autonomic pathways for sleep apnea and the circadian control of the body by genetically deleting the transmitter, glutamate, in transgenic mice. A greater understanding of these pathways is critical in unraveling autonomic nervous system function in health and disease.

自主神经调节的中枢通路是众所周知的，但在生理环境中的特定通路的功能仍然是一个难以捉摸的目标。我们将评估两个生理上重要的自主神经通路的作用，睡眠呼吸暂停和昼夜节律控制的身体遗传删除的递质，谷氨酸，在转基因小鼠。更好地了解这些途径对于解开自主神经系统在健康和疾病中的功能至关重要。