Yeast oxysterol-binding proteins and lipid regulation

酵母氧甾醇结合蛋白和脂质调节

• 批准号: 250263-2006
• 负责人: Beh, Christopher
• 金额: $ 2.42万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2006
• 资助国家: 加拿大
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=337101
• 关键词: Yeast; oxysterol; binding; proteins; lipid

Cholesterol is a necessary evil. Too much cholesterol leads to disease, but some cholesterol is nonetheless needed for normal cell growth. Cholesterol and related lipids are required for the structure of the membrane that envelopes cells, and cholesterol affects the function of proteins embedded within this membrane. Oxysterol-binding proteins (OSBPs) are implicated in the transport of cholesterol within cells and in associated cellular responses. We discovered that yeast OSBPs help determine where on the mother cell a new daughter cell will grow and divide. The goal of our work is to define the mechanism by which yeast OSBPs integrate cholesterol and lipid regulatory signals with the control of cell growth and division. Because yeast and humans possess similar factors required for cell growth, we can exploit yeast molecular genetics to make quick progress towards understanding why cholesterol and OSBPs are important to our cells.

胆固醇是一种必要的邪恶。过多的胆固醇会导致疾病，但一些胆固醇仍然是正常细胞生长所必需的。胆固醇和相关脂质是包裹细胞的膜结构所必需的，并且胆固醇影响嵌入该膜内的蛋白质的功能。氧化固醇结合蛋白（OSBPs）参与细胞内胆固醇的转运和相关的细胞反应。我们发现酵母OSBPs有助于确定母细胞上新的子细胞将生长和分裂的位置。我们工作的目标是确定酵母OSBPs整合胆固醇和脂质调节信号与细胞生长和分裂控制的机制。由于酵母和人类具有细胞生长所需的相似因子，我们可以利用酵母分子遗传学来快速了解为什么胆固醇和OSBPs对我们的细胞很重要。