Characterisation of autophagy deficiency in skeletal muscle homeostasis

骨骼肌稳态中自噬缺陷的表征

• 批准号: nhmrc : 1082253
• 负责人: Dr Meagan Mcgrath
• 金额: $ 63.76万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-autophagy-deficiency-muscle-homeostasis/518862
• 关键词: Characterisation; autophagy; deficiency; skeletal; muscle

Defects in skeletal muscle are a cause of muscle disease, and also have broad health implications for diabetes, obesity and liver disease. As such, it is important to understand the processes required for healthy muscle and how signals communicate from muscle to the liver and fat, which integrate whole body metabolism. This application examines how the cellular degradation process known as autophagy integrates these important processes by investigating a novel gene regulator of this pathway.

骨骼肌缺陷是肌肉疾病的一个原因，并且对糖尿病、肥胖和肝脏疾病也有广泛的健康影响。因此，了解健康肌肉所需的过程以及信号如何从肌肉传递到肝脏和脂肪（整合全身代谢）非常重要。该应用通过研究该途径的新型基因调节因子来研究被称为自噬的细胞降解过程如何整合这些重要过程。