Characterization of ARL6IP5 in hepatitis C-related liver cancer

ARL6IP5 在丙型肝炎相关肝癌中的特征

• 批准号: nhmrc : 1047417
• 负责人: A/Pr Liang Qiao
• 金额: $ 33.69万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterization-arl6ip5-hepatitis-liver-cancer/111935
• 关键词: Characterization; ARL6IP5; hepatitis; related; liver

The incidence and mortality from liver cancer is increasing rapidly in Australia, and hepatitis C virus infection is the most common cause. How hepatitis C leads to liver cancer is largely unknown. We identified a novel gene termed ARL6IP5 that appears to be specifically increased in liver tissue by chronic hepatitis C infection. In this project we will characterize the involvement and role of this gene in liver cancer development. Knowledge gained from this study will help us understand how hepatitis C leads to cancer.

在澳大利亚，肝癌的发病率和死亡率正在迅速增加，丙型肝炎病毒感染是最常见的原因。丙型肝炎如何导致肝癌在很大程度上是未知的。我们发现了一种新的基因ARL6IP5，它似乎在慢性丙型肝炎感染的肝组织中特异性增加。在本项目中，我们将描述该基因在肝癌发展中的参与和作用。从这项研究中获得的知识将帮助我们了解丙型肝炎如何导致癌症。