Characterization of H. pylori –specific CD4 T cell responses and the evaluation of the basic requirements for the development of an effective anti-H. pylori vaccine

幽门螺杆菌特异性 CD4 T 细胞反应的表征以及开发有效抗幽门螺杆菌的基本要求的评估。

• 批准号: nhmrc : 1055014
• 负责人: Dr Senta Walton
• 金额: $ 20.88万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterization-h-pylori-pylori-vaccine/112426
• 关键词: Characterization; H.; pylori; specific; CD4

H. pylori infect over half of the global population. Although infection results in asymptomatic gastritis in most cases 10 % develop gastric ulcers and cancer. Current vaccination strategies have failed to protect humans from infection. We aim to characterise the main immune cells involved in H. pylori infection, specifically the bacteria-specific CD4 T cells. We will then try to understand the basic requirements for a successful vaccine in order to develop new, improved anti-H. pylori vaccines.

H.幽门螺杆菌感染了全球一半以上的人口。虽然大多数情况下感染会导致无症状的胃炎，但仍有10%的人会发展为胃溃疡和癌症.目前的疫苗接种策略未能保护人类免受感染。我们的目标是确定参与H. pylori感染，特别是细菌特异性CD4 T细胞。然后，我们将试图了解成功疫苗的基本要求，以开发新的，改进的抗H。幽门螺杆菌疫苗