Characterization and targeting of precursor exhausted T cells (TPEX) for the treatment of chronic infection and cancer

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The recent discovery of precursor exhausted CD8 T cells (TPEX) has not only allowed us to conceptualize our understanding of how chronic T cell responses are maintained over long periods of time, but also resulted in a new understanding of the mechanisms underpinning checkpoint inhibition. I will undertake critical characterization of these TPEX in chronic viral infections with the goal to reveal phenotypic and functional properties, which will serve as potential novel targets for immunotherapy.