Control of satellite cells during physiological stresses

生理应激期间卫星细胞的控制

• 批准号: 298738-2006
• 负责人: Hawke, ThomasJames
• 金额: $ 2.26万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2006
• 资助国家: 加拿大
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=340437
• 关键词: Control; satellite; cells; during; physiological

The regenerative capacity of skeletal muscle is due to a pool of stem cells, termed satellite cells, which are resident within adult skeletal muscle.  Despite their integral role in muscle growth and regeneration, our understanding of the basic mechanisms regulating these cells has yet to be fully elucidated.  In this proposal we will address some issues related to how muscle satellite cells are regulated in response to exercise and toxin-induced injury.  We will begin by defining the role of a novel protein, Xin, within the muscle satellite cells and clarify its relationship with other known signaling proteins, such as Beta-catenin.  Secondly, we will determine the factors which play a role regulating Xin within the muscle satellite cell population.  Finally, we will evaluate the function of Xin within the whole animal in response to exercise or toxin-induced muscle injury.  The results of these studies will enhance our understanding of the fundamental processes necessary for skeletal muscle hypertrophy and regeneration.

骨骼肌的再生能力归因于干细胞池，称为卫星细胞，它们存在于成人骨骼肌内。  尽管它们在肌肉生长和再生中发挥着不可或缺的作用，但我们对调节这些细胞的基本机制的理解尚未完全阐明。  在本提案中，我们将解决一些与如何调节肌肉卫星细胞以响应运动和毒素引起的损伤相关的问题。  我们将首先定义一种新蛋白 Xin 在肌肉卫星细胞中的作用，并阐明它与其他已知信号蛋白（如 β-连环蛋白）的关系。  其次，我们将确定在肌肉卫星细胞群中发挥调节Xin作用的因素。  最后，我们将评估整个动物中 Xin 对运动或毒素引起的肌肉损伤的反应功能。  这些研究的结果将增强我们对骨骼肌肥大和再生所需基本过程的理解。