Can esomeprazole improve outcomes in women at high risk of pre-eclampsia? A Phase II placebo-controlled randomised, multi-centre clinical trial.

先兆子痫，通过怀孕期间高血压的发展而被认识到，会导致母亲和婴儿的死亡和/或伤害。对先兆子痫发展的进一步了解为疾病的早期预测和预防提供了机会。我们将使用一个强大的预测模型来识别先兆子痫高危妊娠，然后观察一种新的治疗方法（埃索美拉唑）对母体血压和这种疾病的发展的影响。

Pre-eclampsia, recognised through the development of high blood pressure in pregnancy, causes death and/or injury to mothers and babies. An improved understanding of the development of pre-eclampsia has provided opportunities for early prediction and prevention of disease. We will use a powerful predictive model to identify pregnancies at high risk of pre-eclampsia then observe the effect of a novel treatment (esomeprazole) on maternal blood pressure and the development of this disease.