STTR Phase I: Electronic Measurement of Capillary Refill Time to Improve Outcomes from Sepsis

STTR 第一阶段：电子测量毛细血管再充盈时间以改善脓毒症的治疗效果

• 批准号: 2212728
• 负责人: Scott Filer
• 金额: $ 25.58万
• 依托单位: PROMEDIX, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2212728&HistoricalAwards=false
• 关键词: STTR; Phase; Electronic; Measurement; Capillary

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is a novel external system for rapidly diagnosing sepsis by measuring capillary refill time (CRT). Independent clinical studies have demonstrated the utility of CRT for detecting sepsis. Current methods for monitoring capillary refill times rely on physical examinations that are both prone to human error and inconsistency. The company aims to develop an automated diagnostic and monitoring device for objectively and repeatably quantifying capillary refill time for use in a clinical setting. If successful, the technology may have widespread potential use in emergency departments, clinics, ambulances, or at home. This Small Business Technology Transfer (STTR) Phase I project develops a new finger-sensor interface for monitoring CRT that ensures contact between the finger and sensor across a range of finger sizes and validate the system in human use. The objectives are to ensure human factors engineering to enable use in a broad range of patients by a wide range of caregivers. A novel algorithm to improve sensor performance and provide user feedback on noise or aberrant signals will also be integrated. The system will be tested in a group of patients at risk for sepsis to demonstrate the device reliably and accurately measures the CRT across a wide variety of patient demographics and the device is easily usable by a wide range of caregivers including physicians and family members without extensive training. A successful Phase I outcome is a system enabling the consistent ability to collect high-quality measures of CRT in patients at risk for sepsis and to provide the user with ongoing measures of signal quality.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业技术转移（STTR）第一阶段项目的更广泛影响/商业潜力是一种通过测量毛细血管再充盈时间（CRT）快速诊断败血症的新型外部系统。独立的临床研究已经证明了CRT在检测败血症方面的效用。目前监测毛细血管再填充时间的方法依赖于身体检查，这些检查容易出现人为错误和不一致。该公司的目标是开发一种自动诊断和监测设备，用于客观和可重复地量化临床环境中使用的毛细血管再填充时间。如果成功，这项技术可能会在急诊科、诊所、救护车或家庭中得到广泛应用。这项小型企业技术转移（STTR）第一阶段项目开发了一种新的手指传感器接口，用于监测CRT，确保手指和传感器在各种手指尺寸范围内的接触，并验证该系统在人类使用中的有效性。目标是确保人为因素工程，使广泛的护理人员在广泛的患者中使用。一种新的算法，以提高传感器的性能和提供用户反馈的噪音或异常信号也将集成。该系统将在一组有败血症风险的患者中进行测试，以证明该设备可靠且准确地测量了各种患者的CRT，并且该设备易于由包括医生和家庭成员在内的广泛护理人员使用，而无需经过广泛的培训。一个成功的I期结果是，该系统能够在有败血症风险的患者中持续收集高质量的CRT测量数据，并为用户提供持续的信号质量测量。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。