Chemistry of small ring compounds and destabilized carbocations

小环化合物和不稳定碳阳离子的化学

• 批准号: 5884-2006
• 负责人: LeeRuff, Edward
• 金额: $ 2.33万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=361139
• 关键词: Chemistry; small; ring; compounds; destabilized

A new method for preparing a class of medicinal agents (nucleosides) for the use in cancer and viral therapy has been developed in our laboratory. This method has been issued a North American patent. The proposal is to adapt this method to a rapid synthesis approach using polymer supports in order to streamline the synthesis of a large number of compounds (chemical libraries) with slightly modified structures in order to identify potential drug candidates for further development. Chemical modification of these commercial polymers will improve the more wider applications in the area of drug delivery and cosmetics. Another aspect of our research involves the understanding of the chemical processes induced by light interaction. Such research is relevant in the context of photostability of materials.

我们实验室开发了一种制备用于癌症和病毒治疗的一类药物（核苷）的新方法。该方法已获得北美专利。该提案是为了使该方法适应使用聚合物支持的快速合成方法，以简化具有略微修改的结构的大量化合物（化学库）的合成，以鉴定用于进一步开发的潜在候选药物。对这些商品化聚合物进行化学改性，将使其在药物输送和化妆品领域得到更广泛的应用。我们研究的另一个方面涉及对光相互作用引起的化学过程的理解。这种研究与材料的光稳定性有关。