Development of a electro-mechano-fluidic biological model

机电流体生物模型的开发

• 批准号: 249709-2007
• 负责人: Vigmond, Edward
• 金额: $ 2.69万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=361493
• 关键词: Development; electro; mechano; fluidic; biological

Biological tissue can be very complicated to model. Electrical signals can cause cell contraction, The cells exist in a liquid environment which distributes forces from all surrounding cells. The different components of the system interact since cells respond to pressure, stretch, electrical fields, and chemicals. For example, stretching a cell may alter its electrical function which will then alter contraction. The heart is an example of such a system.This project aims to build the most complete model of the heart comprising the following components: a geometrically realistic shape, a functioning electrical system including the fast conduction system, mechanical contraction, blood flow, and functioning heart valves. The model will be composed of three distinct and interacting components: an electrical model, a mechanically contracting model, and a blood flow simulator. Mechanisms that provide feedback between the different parts will be included.The first part of the project will be to build upon an existing model and make it work with more geometrically realistic electrical models. This will properly compute the electrical activation sequence that triggers the mechanical contraction.The second part of the project will improve the speed of the model by implementing a new method for solving the blood flow. The grid to compute the fluid will adapt so that it will have a high degree of detail only where interesting things occur.Finally, the model will be extended so that the effects of applying large electrical shocks, as delivered by therapeutic devices, can be computed.This will be the only complete model of the heart. It will be computationally demanding, but by using the most advanced computational techniques, we will reduce much of the burden. It will be a unique tool for the investigation of many  important cardiac phenomena.

生物组织的建模可能非常复杂。电信号可以引起细胞收缩，细胞存在于液体环境中，该液体环境分配来自所有周围细胞的力。系统的不同组成部分相互作用，因为细胞对压力，拉伸，电场和化学物质做出反应。例如，拉伸细胞可能会改变其电功能，从而改变收缩。心脏是这样一个系统的一个例子。该项目旨在建立最完整的心脏模型，包括以下组件：几何逼真的形状，功能电气系统，包括快速传导系统，机械收缩，血液流动和功能心脏瓣膜。该模型将由三个不同且相互作用的组件组成：电气模型、机械收缩模型和血流模拟器。该项目的第一部分将建立在现有的模型上，并使其与更逼真的几何电气模型一起工作。这将正确地计算触发机械收缩的电激活序列。该项目的第二部分将通过实施一种新的求解血流的方法来提高模型的速度。计算流体的网格将进行调整，只有在有趣的事情发生的地方才有高度的细节。最后，模型将被扩展，以便可以计算施加大电击的影响，如治疗设备所提供的。这将是唯一完整的心脏模型。这将是计算上的要求，但通过使用最先进的计算技术，我们将减少很多负担。它将成为研究许多重要心脏现象的独特工具。