A Novel Metabolic Role for UDP Glycosyltransferase 8 (UGT8)

UDP 糖基转移酶 8 (UGT8) 的新代谢作用

• 批准号: nhmrc : 1085410
• 负责人: Dr Michael Downes
• 金额: $ 27.95万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-metabolic-role-8-ugt8/519084
• 关键词: Novel; Metabolic; Role; UDP; Glycosyltransferase

The UDP glycosyltransferases (UGTs) are a family of enzymes that remove drugs and toxins from the human body as well as control levels of naturally produced molecules such as bile acids and hormones. We found that a new member of this family called UGT8 processes bile acids in the kidney and intestine and can affect how bile acids act to regulate metabolism. Our studies uncover new roles for bile acids in liver, kidney and gut health and in metabolic disorders such as diabetes and obesity.

UDP糖基转移酶(UGT)是一类酶，可以从人体中清除药物和毒素，并控制胆汁酸和激素等自然产生的分子的水平。我们发现，这个家族的一个新成员UGT8处理肾脏和肠道中的胆汁酸，并可以影响胆汁酸如何调节新陈代谢。我们的研究发现了胆汁酸在肝脏、肾脏和肠道健康以及糖尿病和肥胖症等代谢疾病中的新作用。