Steroidogenic factor-1, a novel regulator of hepatic stellate cell function

类固醇生成因子-1，肝星状细胞功能的新型调节剂

• 批准号: nhmrc : 632886
• 负责人: Dr Michael Downes
• 金额: $ 39.31万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/steroidogenic-factor-1-cell-function/77608
• 关键词: Steroidogenic; factor; novel; regulator; hepatic

Recently, we have discovered that steroidogenic factor-1, a specialized protein that directs cells to make steroid hormones, is present in cells in the liver called stellate cells. This may play a vital role in how the liver responds to damage and whether the liver will the scar and move on to cirrhosis. Our experiments will determine if this is so and how this system functions. This work will provide a basis for future treatments to improve or prevent cirrhosis in liver disease patients.

最近，我们发现类固醇生成因子-1，一种指导细胞制造类固醇激素的专门蛋白质，存在于肝脏中称为星状细胞的细胞中。这可能在肝脏如何对损伤做出反应以及肝脏是否会疤痕并转移到肝硬化方面起着至关重要的作用。我们的实验将确定是否如此以及这个系统如何运作。这项工作将为未来改善或预防肝病患者肝硬化的治疗提供基础。