Can Pentoxifylline improve long-term outcomes in preterm infants with late-onset sepsis or necrotizing enterocolitis – a pragmatic, randomized, controlled trial

早产儿死亡和残疾的风险很高。脑损伤通常是由感染或肠道疾病引起的炎症造成的。到目前为止，还没有治疗方法来减少炎症的有害影响。己酮可可碱减少炎症，是早产儿的一种有前途的、安全的、廉价的治疗选择。这项研究将确定己酮可可碱在抗生素的基础上是否能提高早产儿的存活率而不致残。

Very preterm infants are at high risk of death and disability. Brain injury is often the result of inflammation caused by infection or bowel disease. To date, there is no treatment to reduce the harmful effects of inflammation. Pentoxifylline reduces inflammation and is a promising, safe and inexpensive treatment option for preterm infants. This study will determine whether Pentoxifylline in addition to antibiotics improves survival without disability in preterm infants.