Trkb. shc and rasgrf regulate nmda receptor activity

Trkb。

• 批准号: 341947-2007
• 负责人: Meakin, Susan
• 金额: $ 2.19万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2007
• 资助国家: 加拿大
• 起止时间: 2007-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=362693
• 关键词: Trkb.; shc; rasgrf; regulate; nmda

Intercellular communication between cells in the brain involves highly specialized regions of contact, termed synapses, between 2 cells referred to as pre and post-synaptic neurons.  It is here that there is an enrichment of receptors and signaling molecules that facilitate responses to neurotransmitters and growth factors that, in turn, can strengthen and/or weaken a particular synapse.  The increase or loss of particular synapses underlies a process termed plasticity and it is this process by which the brain modulates its neural connections during learning and memory development.  Two different classes of cell surface receptors have been shown to serve important roles in learning and memory.  These are NMDA receptors which are activated by excitatory neurotransmitters in the brain such as glutamate and a receptor termed TrkB which responds to a growth factor termed brain-derived neurotrophic factor.  Since these are 2 very different types of receptors, it has not been well understood how they could both be important to learning and memory and/or if they are working together to regulate this process.       My lab has identified 2 intracellular signaling molecules that can bind to both classes of receptors and which can regulate the activity and signaling properties of each.  This provides us with a unique opportunity to investigate how these 2 receptor classes are 'cross-talking' in the process of learning and memory development.  This is a very unique opportunity to develop a molecular handle on such a fundamental process of developmental circuitry in the brain.

大脑中细胞间的通讯涉及高度专门化的接触区域，称为突触，两个细胞之间称为突触前和突触后神经元。正是在这里，有丰富的受体和信号分子，促进对神经递质和生长因子的反应，反过来，可以加强和/特定突触的增加或丧失是一个被称为可塑性的过程的基础，正是这个过程，大脑在学习和记忆过程中调节其神经连接。发育。两种不同类型的细胞表面受体已被证明在学习和记忆中起重要作用。这些是NMDA受体，其由大脑中的兴奋性神经递质如谷氨酸激活，以及称为TrkB的受体，其响应称为脑源性神经营养因子的生长因子。由于这是两种非常不同类型的受体，它们如何对学习和记忆都很重要和/或它们是否共同调节这一过程还没有得到很好的理解。 我的实验室已经鉴定出2种细胞内信号分子，它们可以与这两类受体结合，并且可以调节每种受体的活性和信号特性。这为我们提供了一个独特的机会来研究这两类受体如何“交叉”-这是一个非常独特的机会，可以发展一个分子处理这样一个基本的发展过程，大脑中的回路