Trkb. shc and rasgrf regulate nmda receptor activity

Trkb。

• 批准号: 341947-2007
• 负责人: Meakin, Susan
• 金额: $ 2.19万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=429962
• 关键词: Trkb.; shc; rasgrf; regulate; nmda

Intercellular communication between cells in the brain involves highly specialized regions of contact, termed synapses, between 2 cells referred to as pre and post-synaptic neurons. It is here that there is an enrichment of receptors and signaling molecules that facilitate responses to neurotransmitters and growth factors that, in turn, can strengthen and/or weaken a particular synapse. The increase or loss of particular synapses underlies a process termed plasticity and it is this process by which the brain modulates its neural connections during learning and memory development. Two different classes of cell surface receptors have been shown to serve important roles in learning and memory. These are NMDA receptors which are activated by excitatory neurotransmitters in the brain such as glutamate and a receptor termed TrkB which responds to a growth factor termed brain-derived neurotrophic factor. Since these are 2 very different types of receptors, it has not been well understood how they could both be important to learning and memory and/or if they are working together to regulate this process.

脑中细胞间的通讯涉及高度专门化的接触区域，称为突触，两个细胞之间称为突触前和突触后神经元。 正是在这里，有一个丰富的受体和信号分子，促进对神经递质和生长因子的反应，反过来，可以加强和/或削弱特定的突触。 特定突触的增加或丧失是一个称为可塑性的过程的基础，大脑在学习和记忆发展过程中正是通过这个过程来调节其神经连接。 两种不同类型的细胞表面受体已被证明在学习和记忆中发挥重要作用。 这些是NMDA受体，其由脑中的兴奋性神经递质如谷氨酸和称为TrkB的受体激活，该受体响应称为脑源性神经营养因子的生长因子。 由于这是两种非常不同类型的受体，因此还没有很好地理解它们如何对学习和记忆都很重要，以及/或者它们是否共同调节这一过程。