新型 ATP 结合胆固醇转运蛋白 ABCA8 调节心脏代谢疾病：新的治疗靶点？-猫眼课题宝

新型 ATP 结合胆固醇转运蛋白 ABCA8 调节心脏代谢疾病：新的治疗靶点？

批准号：

nhmrc : 1148468

负责人：

Prof Kerry-Anne Rye

金额：

$21.11万

依托单位：

The University of New South Wales

依托单位国家：

澳大利亚

项目类别：

Targeted Calls

财政年份：

2018

资助国家：

澳大利亚

项目状态：

已结题

起止时间：

2018-01-01 至 2020-12-31

来源：

https://researchdata.edu.au/regulation-cardiometabolic-disease-therapeutic-target/1321009

关键词：

Regulation cardiometabolic disease novel ATP

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英文摘要

Approximately 1.7 million Australians and 12% of the population in Singapore has type 2 diabetes (T2D). We have identified a cholesterol transporter, ABCA8, the absence of which produces symptoms similar to those seen in humans with T2D. The aim of this project is to understand the molecular basis of the diabetes symptoms in mice that do not have ABCA8 with a view to identifying this transporter as a drug target to reduce T2D and its complications, including heart attacks.

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