The role of endothelial lipase in high density lipoprotein metabolism

内皮脂肪酶在高密度脂蛋白代谢中的作用

• 批准号: nhmrc : 200501
• 负责人: Prof Kerry-Anne Rye
• 金额: $ 8.71万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-endothelial-lipase-lipoprotein-metabolism/100085
• 关键词: role; endothelial; lipase; density; lipoprotein

Atherosclerosis is a major cause of death and disability in Australia. A high level of blood cholesterol increases the risk of developing atherosclerosis. This increase in risk is caused by the cholesterol that is carried in low density lipoproteins (LDL). However, not all cholesterol is bad. A proportion of the cholesterol in blood is carried in high density lipoproteins (HDL), which are powerful protectors against atherosclerosis. As not all HDL protect equally well against atherosclerosis, it is important to know how blood levels of HDL are regulated. In 1999 a new enzyme called endothelial lipase was discovered. Endothelial lipase dramatically decreases HDL levels in mice. The reason why this happens is not known. The main aims of this project are to work out how endothelial lipase decreases HDL levels and whether it decreases the levels of all HDL equally or whether it preferentially decreases the levels of certain types of HDL. The outcome of this project will establish how endothelial lipase affects the ability of HDL to protect against atherosclerosis in humans.

在澳大利亚，动脉粥样硬化是导致死亡和残疾的主要原因。高水平的血液胆固醇会增加患动脉粥样硬化的风险。这种风险的增加是由低密度脂蛋白（LDL）中携带的胆固醇引起的。然而，并非所有的胆固醇都是坏的。血液中的一部分胆固醇是由高密度脂蛋白（HDL）携带的，它是对抗动脉粥样硬化的强大保护剂。由于并非所有的HDL都能同样有效地预防动脉粥样硬化，因此了解HDL的血液水平是如何调节的非常重要。1999年，一种叫做内皮脂肪酶的新酶被发现。内皮脂肪酶显著降低小鼠的HDL水平。发生这种情况的原因尚不清楚。该项目的主要目的是研究内皮脂肪酶如何降低HDL水平，以及它是否同等地降低所有HDL水平，或者它是否优先降低某些类型的HDL水平。该项目的结果将确定内皮脂肪酶如何影响HDL的能力，以防止人类动脉粥样硬化。